Jivantyadi Yamakam combines the lipid-base of sesame oil (Tailam) and clarified butter (Ghritam) infused with a decoction of herbs including Arka (Calotropis gigantea), Jivanti (Leptadenia reticulata), Manjishtha (Rubia cordifolia), Darvi (Berberis aristata), Tutha (blue vitriol), Sarjarasa (Shorea robusta resin), and Madhuchistha (beeswax). This preparation may deliver both fat-soluble and water-soluble phytoactives into the skin, leveraging the emollient and penetrating properties of the base fats to enhance topical absorption. Manjishtha is traditionally known for its antioxidant and "blood-purifying" actions, while Darvi is reputed for anti-inflammatory and mild antibacterial effects; Jivanti is considered rejuvenative, and Arka might help soothe irritation—though pharmacological evidence remains preliminary. The lipid-rich medium of ghee and sesame oil helps deeply moisturize and form a protective layer, supporting skin's barrier function and reducing dryness. Jivantyadi Yamakam is commonly indicated for conditions like eczema, psoriasis, exfoliative or contact dermatitis, xerosis (dry skin), cracked hands, feet, lips always applied externally and under practitioner guidance.