Sikkamjar manapagu is a classical siddha preparation used to treat digestive disorder like indigestion, chest burn, belching, nausea and vomiting. But it also used to improve the blood circulation; healthy living. Recent molecular docking studies claims that sikkanjar manapagu has promising role on reduce the risk of atherosclerosis. Atherosclerosis is a common condition that occurs when plaque builds up in the walls of your arteries, making it difficult for blood to flow. Plaque is made up of cholesterol, calcium, fatty substances, cellular waste products, and fibrin.