Manjishtadi Kashayam is a classical polyherbal formulation with Manjishta (Rubia cordifolia) as the key ingredient, supported by herbs like Guduchi (Tinospora cordifolia), Nimba (Azadirachta indica), Vasa (Adhatoda vasica), Patola, and Amalaki (Emblica officinalis). These herbs are traditionally indicated for disorders of Rakta (blood) and Pitta dosha, playing a significant role in managing skin diseases, inflammatory conditions, and chronic infections. Modern research shows that Manjishta exhibits potent anti-inflammatory, antioxidant, and anti-microbial activity, supporting its classical use in detoxification and skin rejuvenation. The formulation is often prescribed in conditions like eczema, acne, urticaria, and pigmentation issues, and is also used as adjuvant support in liver disorders and joint inflammation.