It is one of the classical siddha medicine that treats PCOD(S), infertility for thousands of years. The star cast of the medicine, Melia dubia & Citrullus colocynthis has specific indication for infertility & its causes. Melaia composite(dubia) is a rare neem tree different from common neem tree called Azadiracta indica. This special neem version has various therapeutic values like anti-bacterial, anti-cancer & rich source of limonoids. Limonoids particularly act against all kind of cancer & benign tumour, also it has silver nanoparticles.in siddha system of medicine it is act against tumorous growth like fibroid uterus, PCOD(S). It treats the significant features of PCOD like size & numbers cyst present in ovaries, hormonal imbalance, increase weight & infertility. It regularizes the vadha dosha & expel out the mensural impurities effectively and administrate during menses.