Mahathikthakam Kashayam is a traditional Ayurvedic formulation prepared using a group of herbs known for their cooling, detoxifying, and balancing properties. Key ingredients like Katuki (Picrorhiza kurroa), Nimba (Azadirachta indica), Guduchi (Tinospora cordifolia), Amalaki (Emblica officinalis), and Haridra (Curcuma longa) are known in Ayurveda to support healthy skin, liver function, and digestion. The formulation is predominantly used to help balance aggravated Pitta and support healthy inflammatory responses within the body. Scientific studies on individual herbs suggest antioxidant, hepatoprotective, and immune-supportive actions that align with its traditional applications. It may assist in maintaining skin clarity and comfort, especially when supported by a Pitta-balancing lifestyle and diet. This decoction is typically prescribed by Ayurvedic practitioners as part of a holistic wellness approach.